The Minnesota-KPMP will recruit and follow-up study participants with chronic kidney disease due to diabetes or hypertension, the most common causes of chronic kidney disease, plus participants with type 1 diabetes who do not have clinical manifestations of kidney disease despite long diabetes…
This study will develop and implement a genomic return of result (gRoR) process in the Framingham Heart Study and Jackson Heart Study cohorts and explore associated medical, behavioral and economic outcomes. The study will also explore ways to automate and streamline genomic variant interpretation…
MPMC’s new initiative is among the six interdisciplinary projects selected to receive Grand Challenges Research Interdisciplinary Team Awards from the Office of the Executive Vice President and Provost. MPMC II focuses on one of the most mature domains of precision medicine – pharmacogenomics (PGx…
The Minnesota Precision Medicine Collaborative (MPMC) is a transformative initiative to use 21st century technologies – including genomics, informatics, bioengineering, analysis of environmental exposures, and behavioral sciences – to tailor health care to the challenges facing individuals and…
This innovative 3-year project, based cooperatively at the University of Minnesota and Vanderbilt University, has convened a national Working Group of top legal and scientific experts to analyze current US federal and state law and regulation on translational genomics and to generate consensus guidance on what the law should be. The federal Precision Medicine Initiative (PMI) aims to use
This 3-year program developed a research educational program – Big Data Coursework for Computational Medicine (BDC4CM) – that instructs students, fellows, and scientists in the use of specific new methods and tools for Big Data by providing tailored, in-depth instruction, hands-on laboratory…
This project addressed recent regulatory amendments that require CLIA-certified and -exempt laboratories that are subject to the HIPAA Privacy Rule to comply with new individual data-access requirements.
This 2-year project generated multiple articles on the question of how to handle incidental findings (IFs) and individual research results (IRRs). The question of whether researchers should return IFs and IRRs of clinical significance challenges the traditional line drawn between research and…
This empirical and normative bioethics research project was created to guide policy and practice about the disclosure of genomic incidental findings (GIFD), a much-debated topic. With ethical guidance from a multidisciplinary ELSI Working Group, we conducted an experiment designed to develop strategies for offering incidental findings to family members of probands in a biobank for pancreatic
This 2-year project convened a multidisciplinary working group of national experts to analyze and generate recommendations on managing incidental findings and individual research results in genomic research using biobanks and large archives. In order to understand the genetic contribution to a host…
This funding encompasses work on two related projects addressing cutting-edge issues posed by the latest advances in biomedical science in the linked domains of genomics and reproductive technologies. Both raise high-profile issues of immediate concern to federal and state government, scientists,…
This project, led by researchers at the University of Minnesota collaborating with a working group of prominent national scholars, tackled how researchers should handle incidental findings identified during research. Incidental findings are defined as unexpected findings beyond the domain of key…
This project explored the impending collision between biological and regulatory classifications of population subgroups in American society. Researchers focused on the interaction between biological categories emerging from the effort to create a haplotype map of the human genome and preexisting…
This grant was awarded to the Center for Bioethics and Joint Degree Program in Law, Health & the Life Sciences to complete a comprehensive investigation of the ethical, legal, and policy issues in the use of genetic information in private and public disability insurance and to recommend…