Minnesota Precision Medicine Collaborative (MPMC) II: Toward Pharmacogenomics-Enabled Healthcare at Statewide Scale — Implementing Precision Medicine

Award Amount
Project Dates
01/01/2019 to 01/31/2021
Principal Investigator

Constantin Aliferis, MD, MS, PhD, FACMI (Institute for Health Informatics)
Pamala Jacobson, PharmD, FCCP (College of Pharmacy)
Catherine McCarty, PhD, MPH (Medical School, Duluth)
Susan M. Wolf, JD (Consortium on Law and Values in Health, Environment & the Life Sciences)

MPMC’s new initiative is among the six interdisciplinary projects selected to receive Grand Challenges Research Interdisciplinary Team Awards from the Office of the Executive Vice President and Provost. MPMC II focuses on one of the most mature domains of precision medicine – pharmacogenomics (PGx), which despite its proven scientific basis and immense promise has not yet been widely implemented in healthcare systems. 

Integration of Oncology PGx in a Large Rural Health System, Essentia Health-Duluth
Leads: Jacob Brown, David Stenehjem, Stephen C. Waring
Team Members: Bret E. Friday, David J. Sperl, Dianne L. Witten

Implementation of Pharmacogenomics Testing for Psychiatric Disorders in Fairview Outpatient Clinics and the Northern Pines Mental Health Center
Leads: Jeffrey R. Bishop, Joel F. Farley, Robert B. Jones, Allyson M. Schlichte, Randall Seifert, Todd
Sorensen, Bharat Thyagarajan
Team Members: Meena N. Murugappan, Sharon Ng, Laura Schwartzwald, Lindsay A. Sorge

State Pharmacogenomics Experts Committee
Leads: Jeffrey R. Bishop, Jacob Brown, Pamala Jacobson
Team Members: David Gregornik, Edris Kosar, Wayne T. Nicholson, Heather Zierhut

Health Economic Analyses for Pharmacogenomics
Leads: Joel F. Farley, Pinar Mandic
Team Members: Zachary Rivers, Stephen Schondelmeyer, Susan M. Wolf

Pharmacogenomics Technology & Clinical Decision Support Architecture
Leads: Constantin Aliferis, Jeffrey R. Bishop, Steve Johnson
Team Members: Pedro J. Caraballo, David Gregornik, Stephen C. Waring

Pharmacogenomics Education Task Force
Leads: Jyothsna Giri, R. Stephanie Huang, Pamala Jacobson
Team Members: Jeffrey R. Bishop, Jacob Brown, Edris Kosar, Catherine A. McCarty, Zachary Rivers, Randall Seifert, Brian Van Ness

Ethical, Legal and Social Issues at State Level
Lead: Susan M. Wolf
Team Members: Bonnie LeRoy, Catherine A. McCarty, William McGeveran, Duane Quam, Daniel Schwarcz, Richard R. Sharp, Bharat Thyagarajan, Heather Zierhut

Research Platform and Genomic Repository at State Scale
Leads: Constantin Aliferis, Suzette J. Bielinski, Pamala Jacobson, Catherine A. McCarty, Susan M. Wolf
Team Members: John Capacchione, Samuel A. Roiko, Liewei Wang, Stephen C. Waring, Richard Weinshilboum

Resulting Publications

Bishop JR, Huang RS, Brown JT, Mroz P, Johnson SG, Allen JD, Beilinski SJ, England J, Farley JF, Gregornik D, Giri J, Kroger C, Long SE, Luczak T, McGonagle EJ, Ma S, Matey ET, Mandic PK, Moyer AM, Nicholson WT, Petry N, Pawloski PA, Schlichte A, Schondelmeyer SW, Seifert RD, Speedie MK, Stenehjem D, Straka RJ, Wachtl J, Waring SC, Van Ness B, Zierhut HA, Aliferis C, Wolf SM, McCarty CA, Jacobson PA. Pharmacogenomics education, research and clinical implementation in the state of MinnesotaPharmacogenomics  2021:(Epub ahead of print). Download PDF (482.94 KB)