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Popular understanding of genetics has long influenced how Americans think about and treat people viewed as having an inherited "disability." This was true in the years immediately following the rediscovery of Mendelian genetics a century ago, leading to the so-called "age of eugenics." It remains true today, in the age of human gene therapy. In this lecture, Larson draws on the history of eugenic lawmaking and recent developments in anti-discrimination law to explore the meaning of human gene therapy for "disability rights."