Minnesota Precision Medicine CKD & Resilient Diabetes Recruiting Site: Engagement, Enrollment & Ethics

Kidney Illustration
Award Amount
Project Dates
09/15/2022 to 06/30/2027
Principal Investigator

Patrick H. Nachman, MD (University of Minnesota)
Maria Luiza A. Caramori, MD, PhD (Cleveland Clinic)

Susan M. Wolf, JD (University of Minnesota)
Paul E. Drawz, MD, MHS, MS (University of Minnesota) 
Tasma Harindhanavudhi, MD, MS (University of Minnesota)
Sami Safadi, PhD (University of Minnesota) 
Michael S. Rosenberg, MD (University of Minnesota)
Siobhan M. Flanagan, MD (University of Minnesota) 
Lihong Bu, PhD (University of Minnesota)
Oyedele Adeyi, MD (University of Minnesota) 
Sisi Ma, PhD (University of Minnesota)

Project Description

The Minnesota Kidney Precision Medicine Project (Minn-KPMP) will become a recruitment site for the Kidney Precision Medicine Project (KPMP), a consortium of leading research institutions applying the tools of precision medicine to understand and develop new treatments for chronic kidney disease (CKD) and acute kidney injury (AKI). A hallmark of KPMP has been partnership with patients and research participants, including an active Community Engagement Committee.

Minn-KPMP will focus on diabetic and hypertensive patients with and without CKD. The project will engage a diverse patient and participant population, using community-based participatory research (CBPR) methods. The research team will elicit the perspectives of local communities on inclusive recruitment and on ethical issues including research-directed kidney biopsies, return of results, genetic testing, and biobank governance.

The Consortium on Law and Values will lead on research concerning the ethical issues. The team will work with an Ethics Advisory Board consisting of three leading experts:

  • Shawneequa Callier, JD, MA - Associate Professor, Department of Clinical Research & Leadership, George Washington University School of Medicine and Health Sciences (SMHS); Special Volunteer, Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH 
  • S. Malia Fullerton, DPhil - Professor of Bioethics & Humanities, University of Washington School of Medicine; Adjunct Professor, UW Departments of Epidemiology, Genome Sciences, and Medicine (Medical Genetics);  Affiliate Investigator, Public Health Sciences Division, Fred Hutchinson Cancer Research Center 
  • Pilar N. Ossorio, PhD, JD - Professor of Law & Bioethics, University of Wisconsin - Madison Law School and Medical School Department of Medical History & Bioethics; Inaugural Ethics Scholar-in-Residence, Morgridge Institute for Research